Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts.
نویسندگان
چکیده
Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.
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عنوان ژورنال:
- Infection and immunity
دوره 67 5 شماره
صفحات -
تاریخ انتشار 1999